For Your Health & Wellness
Educational Purposes
Christine Foutch - Holistic Physician
Early within the 1900s, the average individual took in about only 15-grams of the Monosaccharide or the simple-sugar Fructose daily. So, Fructose, which can also be called Fruit Sugar, was once a much smaller part of our Human Diet. With the majority of the fructose coming from consuming the whole foods, such as healthier fruits, and vegetables.
Glucose is the principal circulating simple sugar within us animals. While Sucrose, which is a Disaccharide formed by the bonding of the equal parts of the simple-sugars Glucose and Fructose together and so form Sucrose… which is the predominant circulating sugar in plants.
Plants obviously form the basis of the food chain…
The herbivores the animals that feed off the plants and then the omnivores\the animals that feed off both the Plants and the Animals; are all highly adapted, to say the least… For the use of sucrose the Disaccharide; broken down and used for all their energetic purposes which will then obviously translate into the bio-synthetic abilities and then of the course bodily needs.
The major natural sources of fructose in the human diet are Fruits, Honey, and Sucrose\table-sugar.
Under what is considered to be the normal dietary intake; the majority of our ingested fructose becomes metabolized by the Enterocytes once absorbed.
As I said… These Enterocytes which are the absorptive cells within the Small Intestine; absorbing the simplified nutrients, which are also known as chemicals after their chemical breakdown from the enzymatic activity that is taking place within the intestinal lumen; the hollow tubular-passageway; the Alimentary Canal.
Within the Enterocyte, fructose is primarily converted or maybe I should say metabolized to Glucose; with the rearrangement of the atoms there within the molecule. Which is then delivered now as Glusoce out of the enterocyte and into systemic-circulation for utilization by the bodily cells.
However, added in with the converted product now of glucose, you will find that fructose, the remaining molecules thereof are also converted.
Those Carbon-Atoms from the consumed Dietary-Fructose become rearranged; going onto to be metabolized\converted as well through the enzymatic activity there within the Intestinal Enterocytes\the absorptive cells; into many other metabolites. This will now include glycerate, glutamate, glutamine, alanine, ornithine, and citrulline.
Diets that are containing the larger amounts of Sucrose, the high fructose corn syrup, or even just fructose alone, overwhelm this ability to reform the simplified chemicals there within the small intestine enterocyte; altering the metabolism of fructose, therefore, it goes on and enters the systemic circulation.
Under these circumstances, the fructose metabolism, the responsible party that is, becomes left up to the Liver and to a lesser extent the Skeletal Muscle and other tissues of the body.
The simple sugars are by far the predominant carbohydrates absorbed in the digestive tract; as in animals, they are the most important source of energy.
However, the Monosaccharides are rarely found in our normal diets. Rather, they are derived from the enzymatic activity that is described there-above within this article; coming from the digestion of those more complex carbohydrates within the Lumen of the small intestine. The hollow home for digestion.
Particularly, the important dietary carbohydrates will include starch and disaccharides such as lactose and sucrose; but, none of these larger molecules can be absorbed into the enterocyte. For the very simple reason of… they cannot cross the cellular membranes; this is unlike the situation for the monosaccharides, as they have the help from the GLUTs - transporters to carry them across.
Fructose does not circulate at the higher levels in us animals; so, the ingested fructose is believed to be uniquely positioned to convey signals related to our sugar consumption.
Therefore, understanding the mechanisms by which fructose is sensed, you could say may help you with the understanding of our adaptive physiological responses to sucrose metabolism as well as any potential consequences to any excessive sugar consumption.
For Your Health & Wellness
Educational Purposes
Christine Foutch
Holistic-Physician
file:///C:/Users/foutc/Downloads/Fructose%20metabolism%20and%20metabolic%20disease%20.pdf
file:///C:/Users/foutc/Downloads/FRUCTOSE%20METABOLISM%20.pdf
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